Hypertension

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High blood pressure is a common condition that puts extra stress on blood vessels and vital organs. Around 25 per cent of all adults in the UK have the condition, which is also known as hypertension. Spotting high blood pressure symptoms early is crucial, as patients are more at risk of some deadly complications, including heart attacks and strokes. You could be at risk of hypertension if you notice your eyesight has become slightly blurry, it’s been revealed. Blurred vision could be an early warning sign of high blood pressure, warned Bupa. You may be blinking more than usual to try and focus on something specific, or rubbing your eyes to get a clearer view. While it may be caused by simply getting older, or needing to update your prescription at the opticians, it could also be caused by high blood pressure. Problems with your eyes are actually one of the more serious signs of high blood pressure, it warned. “High blood pressure [hypertension] is a serious condition that ca...

It’s not just your heart health you’ll improve when you manage your blood pressure. A national study found that optimizing blood pressure targets could help your memory too. Advertising Policy Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy While people’s blood pressure (BP) fluctuates all the time, the ideal BP target is 120 over 80. The first number (systolic BP) indicates the pressure against your artery walls when the heart beats. The second number (diastolic BP) indicates the pressure against your artery walls when your heart is resting between beats. Over the years, medical guidelines have suggested managing systolic pressure to different targets, from under 140 to under 130, with recent guidelines suggesting management to under 130. Doctors typically give more attention to the first number because it’s the major risk for cardiovascular disea...

Cynthia Brown had been taking the drug valsartan for about two years when she learned last August that it had been recalled over fears of potential carcinogen contamination. Brown, a writer and patient advocate living near Cincinnati, had been prescribed valsartan to control shortness of breath related to primary pulmonary hypertension, but suddenly she had a whole new concern: cancer. “I’ve always been very conscientious about my health. I never dreamed I’d be on all these medications, and I’m real funny about what I take,” Brown, 65, says. “Valsartan has made me leery of all medications.” Brown is just one of the patients affected by a string of drug recalls dating back to last summer. Dozens of batches of generic drugs including valsartan, irbesartan and losartan have been recalled by a variety of manufacturers because they may contain amounts of nitrosamine impurities that exceed current safety standards, the Food and Drug Administration (FDA) announced . Nitrosamine impuriti...

High blood pressure is a common condition that puts extra stress on blood vessels and vital organs. Around 25 per cent of all adults in the UK have the condition, which is also known as hypertension. Spotting high blood pressure symptoms early is crucial, as patients are more at risk of some deadly complications, including heart attacks and strokes. You could be at risk of hypertension if you notice your eyesight has become slightly blurry, it’s been revealed. Blurred vision could be an early warning sign of high blood pressure, warned Bupa. You may be blinking more than usual to try and focus on something specific, or rubbing your eyes to get a clearer view. While it may be caused by simply getting older, or needing to update your prescription at the opticians, it could also be caused by high blood pressure. Problems with your eyes are actually one of the more serious signs of high blood pressure, it warned. “High blood pressure [hypertension] is a serious condition that ca...

Theravance Biopharma has dosed the first patient in a Phase III clinical trial investigating the efficacy, safety and tolerability of ampreloxetine (TD-9855) for the treatment of patients with symptomatic neurogenic orthostatic hypotension (nOH). Ampreloxetine is currently being studied as a once-daily norepinephrine reuptake inhibitor (NRI) for use in the treatment of patients with symptomatic nOH, a rare disorder characterised by sustained orthostatic fall in systolic blood pressure (SBP) or diastolic blood pressure (DBP) within three minutes of standing. Theravance aims to enrol around 188 patients for the four-week, multi-centre, randomised, double-blind, placebo-controlled, parallel-group trial. The trial will include patients with symptomatic nOH caused by primary autonomic failure related to multiple system atrophy (MSA), Parkinson’s disease (PD) and pure autonomic failure (PAF). “We recognise a significant opportunity exists for a potentially safe and durable treatment...

The Pulmonary Hypertension Association recently designated Banner Health’s Cardiovascular Institute of North Colorado a Regional Clinical Program for its pulmonary hypertension program. Located at 1800 15th St., #340A in Greeley, the Cardiovascular Institute’s program is the only one in the state with the Regional Clinical Program designation. The next closest regional clinical program is located in Dallas, Texas, with a total of six in the U.S. The Pulmonary Hypertension Association launched the Pulmonary Hypertension Care Centers accreditation program in 2014 to help patients with the life-threatening lung disease get care from expert clinicians. Also known as high blood pressure of the lungs, pulmonary hypertension affects people of all ages and ethnic backgrounds. The disease can result from the arteries in the lungs becoming damaged, narrowed or stiffened, which forces the right side of the heart to pump with additional force and leads to right heart failure and death. Common ...

January 28, 2019 Share this content: A gene panel was designed to focus on all exons and included BMPR-2, EIF2AK4, TBX4, CAV1, SMAD9, KCNK3, ACVRL1, BMP9, ENG, and BMP10. Heritable pulmonary arterial hypertension (PAH) involves mutations in genes other than Bone Morphogenetic Protein Receptor Type 2 ( BMPR-2 ), according to a study published in the  European Respiratory Journal.  The roles of  TBX4 ,  BMP9 , and  BMP10 , a new gene in PAH, have been bolstered by this research. This study included 268 participants with PAH that was familial or sporadic (n=181), induced by toxins or drugs (n=13), linked with a familial history (n=11), or sporadic pulmonary veno-occlusive disease/pulmonary capillary hemangiomatosis (PVOD/PCH; n=63). A gene panel was designed to focus on all exons and included  BMPR- 2 ,  EIF2AK4 ,  TBX4 ,  CAV1 ,  SMAD9 ,  KCNK3 ,  ACVRL1 ,  BMP9 ,  ENG , and  BMP10 . Using this gene pan...

News Release Monday, January 28, 2019 Major NIH-funded clinical trial adds nuanced evidence linking brain and vascular health. Intensive lowering of blood pressure did not significantly reduce dementia risk but did have a measurable impact on mild cognitive impairment (MCI), according to the final, peer-reviewed results from the Systolic Blood Pressure Intervention Trial (SPRINT) Memory and Cognition in Decreased Hypertension (SPRINT MIND). SPRINT MIND secondary results are the first to show an intervention that significantly reduces the occurrence of MCI, which is a well-established precursor of dementia. The results were reported Jan. 28, 2019 in the Journal of the American Medical Association . SPRINT MIND was an integral aspect of the initial design for SPRINT, a large, randomized clinical trial of intensive blood pressure lowering on cardiovascular and renal disease; both were funded by the National Institutes of Health. “Dementia continues to be a large public health challen...

One in three Americans lives with hypertension, although many aren't aware they have it, according to the Centers for Disease Control and Prevention. (KATV Photo) LITTLE ROCK (KATV) —  The U.S. Food and Drug Administration's (FDA) online recall list of drugs designed to treat hypertension continues to grow, causing concern for pharmacists and patients alike. In July 2018, the FDA began recalling valsartan products manufactured in China because it contained a cancer-causing substance. Over the past several months, the federal government has recalled certain makes of valsartan, losartan and irbesartan, all of which are drugs used in treating high blood pressure. Other manufacturers have voluntarily recalled medicines that contain the three drugs in question. Last week, Torrent Pharmaceuticals Limited called back on losartan potassium tablets due to trace amounts of a substance linked to causing cancer. Pharmacies across the country have scrambled to ensure patients ...

A new study using Pop-Up health check stations found a possible link between 'unhealthy' shopping centres and the number of cases of suspected or diagnosed high blood pressure recorded for people who volunteered for checks. Researchers from City, University of London set up the one day Pop-Up health check stations in seven shopping centres across England, and invited passers-by to have a test to screen for signs of the eye disease, glaucoma. The testing was led by optometrist, Laura Edwards, from the University. Blood pressure readings were also offered 50 per cent of the time to attract potential volunteers with a more comprehensive and familiar health screening. It is well known that persistent high blood pressure (hypertension) can increase your risk of a number of serious and potentially life-threatening conditions including heart attack, and stroke. The research team classed retail outlets in shopping centres as 'unhealthy' if they were either a fast-food take...

Please enable Javascript to watch this video (CNN) — The US Food and Drug Administration is warning of a shortage of a class of drugs used by millions to treat high blood pressure. The drugs known as ARBs, or  angiotensin II receptor blockers , contain valsartan. "Valsartan products are in shortage, and we know that other types of products may fall into shortage soon," FDA Commissioner Dr. Scott Gottlieb and FDA director of drug evaluation and research Dr. Janet Woodcock said in a  statement  released Friday. The warning comes as a growing list of the drugs containing  valsartan ,  losartan  and  irbesartan  have been recalled from the market for containing an impurity that presents a cancer risk. That impurity was discovered in July when FDA lab tests determined that some medications containing valsartan were contaminated with a chemical called NDMA, an environmental contaminant and possible carcinogen. The FDA said its ongoing invest...

Source: Pexels. Making changes to your  diet  is a proven way to help control high blood pressure. These changes can also help you lose weight and lower your chance of heart disease and stroke. High blood pressure (hypertension) is the largest preventable and treatable risk factor for chronic disease in the world. More than 85 million people (1 in 3 adults) in the United States and more than 1 billion (40% of adults) in the world have hypertension. It is a major risk factor for stroke, heart attack, heart failure, and kidney failure. However, because it rarely produces symptoms, many people don’t know they have it, while many who have it do not control it adequately. Adapting the DASH Diet Hundreds of studies attest to the significant benefits of diet on blood pressure. The Dietary Approaches to Stop Hypertension (DASH) diet is the most tested and practical of the dietary approaches. It’s not really a diet, per se, but a way of eating specifically designed for ...

High blood pressure is a common condition that affects more than a quarter of all adults in the UK. The condition, which is also known as hypertension, increases the risk of some deadly complications, including heart attacks and strokes. It’s caused by not doing enough exercise, or eating an unhealthy diet, and it puts extra stress on your blood vessels. You could be at risk of uncontrolled hypertension, and should speak to a doctor straight away, if you are having trouble speaking. Struggling to speak normally could be a sign of deadly high blood pressure , warned medical website LiveStrong. Similarly, struggling to understand what someone else is saying could also be caused by the condition, it said. It’s crucial that you speak to a medical professional straight away if you have high blood pressure and have trouble speaking. It could lead to sudden death, it claimed. “When not controlled, blood pressure levels can rise to the point that you start to experience physical sympt...

Jeff D. Williamson, MD, MHS Lowering blood pressure to a target of 120 mm Hg versus 140 mm Hg did not significantly reduce the risk of dementia in older adults with hypertension, according to the full results of the Systolic Blood Pressure Intervention Trial (SPRINT) Memory and Cognition in Decreased Hypertension (SPRINT MIND), despite promising preliminary results . The study randomized 9361 participants with a mean age of 67.9 years to either the intensive blood pressure control group (target BP of 120 mm Hg) or the standard treatment group (target BP of 140 mm Hg). The study reported adjudicated probable dementia in 149 participants in the intensive treatment group compared to 176 in the standard treatment group, with a hazard ratio (HR) of .83 (95% CI, .67-1.04). “Dementia continues to be a large public health challenge, and based on the primary results of this study, we still have yet to find an intervention strategy proven to reduce the risk of dementia,” said Richard J. Hodes,...

High blood pressure is a common condition that affects more than a quarter of all adults in the UK. The condition, which is also known as hypertension, increases the risk of some deadly complications, including heart attacks and strokes. It’s caused by not doing enough exercise, or eating an unhealthy diet, and it puts extra stress on your blood vessels. You could be at risk of uncontrolled hypertension, and should speak to a doctor straight away, if you are having trouble speaking. Struggling to speak normally could be a sign of deadly high blood pressure , warned medical website LiveStrong. Similarly, struggling to understand what someone else is saying could also be caused by the condition, it said. It’s crucial that you speak to a medical professional straight away if you have high blood pressure and have trouble speaking. It could lead to sudden death, it claimed. “When not controlled, blood pressure levels can rise to the point that you start to experience physical sympt...

January 28, 2019 Share this content: A gene panel was designed to focus on all exons and included BMPR-2, EIF2AK4, TBX4, CAV1, SMAD9, KCNK3, ACVRL1, BMP9, ENG, and BMP10. Heritable pulmonary arterial hypertension (PAH) involves mutations in genes other than Bone Morphogenetic Protein Receptor Type 2 ( BMPR-2 ), according to a study published in the  European Respiratory Journal.  The roles of  TBX4 ,  BMP9 , and  BMP10 , a new gene in PAH, have been bolstered by this research. This study included 268 participants with PAH that was familial or sporadic (n=181), induced by toxins or drugs (n=13), linked with a familial history (n=11), or sporadic pulmonary veno-occlusive disease/pulmonary capillary hemangiomatosis (PVOD/PCH; n=63). A gene panel was designed to focus on all exons and included  BMPR- 2 ,  EIF2AK4 ,  TBX4 ,  CAV1 ,  SMAD9 ,  KCNK3 ,  ACVRL1 ,  BMP9 ,  ENG , and  BMP10 . Using this gene pan...

DUBLIN--(BUSINESS WIRE)--Jan 28, 2019--The "Pulmonary Arterial Hypertension - Pipeline Insight, 2019" drug pipelines has been added to ResearchAndMarkets.com 's offering. Pulmonary Arterial Hypertension - Pipeline Insight, 2019 report offers comprehensive Insight of the pipeline (under development) therapeutics scenario and growth prospects across Pulmonary Arterial Hypertension development. The report provides detailed coverage of the pipeline landscape for this mechanism of action, equipped with data from multiple sources with complete pipeline analysis by developmental stage, associated indications, route of administration and molecule type. Pipeline therapeutics development coverage provides descriptive product profiles including (but not limited to) drug description, product development and R&D activities encompassing clinical and pre-clinical studies, designations, collaborations, licensing deals, grants, technologies and patent details. The report assess...

http://bit.ly/2UumiL9   DUBLIN , PRNewswire/ --  Theravance Biopharma  Inc. (NASDAQ: TBPH) ("Theravance Biopharma" or the "Company") today announced dosing of the first patient in a registrational Phase 3 clinical trial of ampreloxetine (TD-9855) in patients with symptomatic neurogenic orthostatic hypotension (nOH). Ampreloxetine is an investigational, once-daily norepinephrine reuptake inhibitor (NRI) in development for the treatment of patients with symptomatic nOH. The Phase 3 study is a four-week, multi-center, randomized, double-blind, placebo-controlled, parallel-group study designed to evaluate the efficacy, safety and tolerability of ampreloxetine in approximately 188 patients with symptomatic nOH caused by primary autonomic failure associated with multiple system atrophy (MSA), Parkinson's disease (PD) and pure autonomic failure (PAF). Patients will be randomized to receive a single 10 mg dose of ampreloxetine or placebo once daily for four we...

High blood pressure , or hypertension, can lead to serious health problems if left untreated, such as heart attacks and strokes. Blood pressure can be lowered by making dietary changes, including cutting down on salt  and foods high in saturated fat. As well as cutting down on unhealthy foods, it may be worth adding foods to your diet that have properties which can help to improve blood vessel function and reduce blood pressure. One snack which has been shown in certain studies to help lower blood pressure, is yoghurt. According to dietitian Juliette Kellow, a landmark study in the late 1990s found that adding low-fat dairy to a diet rich in fruit and vegetables lowered blood pressure more than fruit and vegetables alone. Further research since has backed up the link, and shown that “yoghurt in particular has impressive results”, said Kellow. According to the dietitian, eating yoghurt five times a week can lead to a 20 per cent drop in the risk of developing high blood pres...

The brain’s system for removing waste is driven primarily by the pulsations of adjoining arteries, University of Rochester neuroscientists and mechanical engineers report in a new study. They also show that changes in the pulsations caused by high blood pressure slow the removal of waste, reducing its efficiency. This might explain the association between high blood pressure and Alzheimer’ disease, the researchers say. Alzheimer’s, the most common cause of dementia among older adults, is characterized by abnormal clumps and tangled bundles of fibers in the brain. The study, reported in  Nature Communications , builds upon groundbreaking discoveries about the brain’s waste removal system by Maiken Nedergaard, co-director of the University’s  Center for Translational Neuromedicine . Nedergaard and her colleagues were the first to describe how cerebrospinal fluid is pumped into brain tissue and flushes away waste. Subsequent research by her team has shown that this glymphati...