Hypertension

This morning Sentinel Healthcare , a Seattle-based remote monitoring platform for patients with hypertension or other chronic diseases in need of management, announced that it has raised $2 million in new funding. The round was led by PSL Ventures. What they do Sentinel provides a wearable blood pressure cuffs and patient smartphone app that transmit data to the company’s wider service. This data is collected and displayed to the company’s physician team, who can help flag high-risk patients and coordinate an appropriate intervention with the patient’s care team. The platform also facilitates two-way communication between the patient and their provider, and handles insurance billing for its customers. “Hypertension is a silent epidemic that kills more people each year than cancer. Despite the existence of multiple effective medications for the disease, most hypertensive patients struggle to achieve blood pressure control,” Dr. Nirav Shah, CEO and founder of Sentinel, said in a stat...

Shen-Cun Fang, 1,2 Wen Huang, 2 Ying-Ming Zhang, 1 Hai-Tao Zhang, 1 Wei-Ping Xie 2 1 Department of Respiratory Medicine, Nanjing Chest Hospital, Nanjing, Jiangsu, China; 2 Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China Background: Hypertension (HTN) is a common adverse event of the vascular endothelial growth factor pathway inhibitor apatinib. This study was conducted to evaluate the association of apatinib-induced HTN with clinical outcomes in patients with advanced non-small-cell lung cancer (NSCLC). Methods: We retrospectively analyzed 110 consecutive patients with advanced NSCLC who were treated with apatinib from August 2014 to January 2018. All patients were classified as normotensive or hypertensive based on blood pressure measurements after initiating therapy. Therapeutic response, progression-free survival (PFS), and overall survival (OS) were evaluated. Univariate and multivari...

Did you know that the majority of the people who have hypertension don’t know it? That’s why it is referred to as “silent killer” because those who have it don’t have symptoms. So what is Hypertension? It is a disorder of having unusually high levels of blood pressure. Hypertension is also known as High Blood Pressure. What causes Hypertension? There are many causes of hypertension. They include; age, size, weight, lack of exercise and diseases such as kidney problems, heart disease, diabetes, and many others. Are you ready to make positive transformations to aid in effectively managing your high blood pressure naturally? Here is how to get started. 1.Eat a Healthy Diet The practical way of managing hypertension naturally is by eating healthy. Changing your eating habits is not easy but worth doing so. You should eat food products that are low on fats; this is because it maintains your blood pressure level hence decreasing the risk of you getting hypertension. You should conside...

Nearly half of all U.S. adults have some type of cardiovascular disease, with the vast majority suffering from high blood pressure, states a new report from the American Heart Association. Over 121 million adults—or 48% of the population—had coronary heart disease, heart failure, stroke, or high blood pressure (hypertension) in 2016, according to the report , which was published Thursday in the AHA journal Circulation . Excluding high blood pressure, this figure falls to 9% of the population. The rise in cardiovascular disease is due in large part to the redefining of hypertension. In 2017, the AHA and American College of Cardiology changed the definition of high blood pressure to be a reading of 130/80, a drop from the previous definition of 140/90. “We’re becoming more and more aware of the importance of high blood pressure. Levels we used to think were normal we now associate with worse outcomes, and treating them makes a big difference,” said Dr. Emelia J. Benjamin, a professo...

High blood pressure is a common condition that puts extra stress on blood vessels and vital organs. Around 25 per cent of all adults in the UK have the condition, which is also known as hypertension. Spotting high blood pressure symptoms early is crucial, as patients are more at risk of some deadly complications, including heart attacks and strokes. You could be at risk of hypertension if you notice your eyesight has become slightly blurry, it’s been revealed. Blurred vision could be an early warning sign of high blood pressure, warned Bupa. You may be blinking more than usual to try and focus on something specific, or rubbing your eyes to get a clearer view. While it may be caused by simply getting older, or needing to update your prescription at the opticians, it could also be caused by high blood pressure. Problems with your eyes are actually one of the more serious signs of high blood pressure, it warned. “High blood pressure [hypertension] is a serious condition that ca...

Jeff D. Williamson, MD, MHS Lowering blood pressure to a target of 120 mm Hg versus 140 mm Hg did not significantly reduce the risk of dementia in older adults with hypertension, according to the full results of the Systolic Blood Pressure Intervention Trial (SPRINT) Memory and Cognition in Decreased Hypertension (SPRINT MIND), despite promising preliminary results . The study randomized 9361 participants with a mean age of 67.9 years to either the intensive blood pressure control group (target BP of 120 mm Hg) or the standard treatment group (target BP of 140 mm Hg). The study reported adjudicated probable dementia in 149 participants in the intensive treatment group compared to 176 in the standard treatment group, with a hazard ratio (HR) of .83 (95% CI, .67-1.04). “Dementia continues to be a large public health challenge, and based on the primary results of this study, we still have yet to find an intervention strategy proven to reduce the risk of dementia,” said Richard J. Hodes,...

High blood pressure is a common condition that affects more than a quarter of all adults in the UK. The condition, which is also known as hypertension, increases the risk of some deadly complications, including heart attacks and strokes. It’s caused by not doing enough exercise, or eating an unhealthy diet, and it puts extra stress on your blood vessels. You could be at risk of uncontrolled hypertension, and should speak to a doctor straight away, if you are having trouble speaking. Struggling to speak normally could be a sign of deadly high blood pressure , warned medical website LiveStrong. Similarly, struggling to understand what someone else is saying could also be caused by the condition, it said. It’s crucial that you speak to a medical professional straight away if you have high blood pressure and have trouble speaking. It could lead to sudden death, it claimed. “When not controlled, blood pressure levels can rise to the point that you start to experience physical sympt...

January 28, 2019 Share this content: A gene panel was designed to focus on all exons and included BMPR-2, EIF2AK4, TBX4, CAV1, SMAD9, KCNK3, ACVRL1, BMP9, ENG, and BMP10. Heritable pulmonary arterial hypertension (PAH) involves mutations in genes other than Bone Morphogenetic Protein Receptor Type 2 ( BMPR-2 ), according to a study published in the  European Respiratory Journal.  The roles of  TBX4 ,  BMP9 , and  BMP10 , a new gene in PAH, have been bolstered by this research. This study included 268 participants with PAH that was familial or sporadic (n=181), induced by toxins or drugs (n=13), linked with a familial history (n=11), or sporadic pulmonary veno-occlusive disease/pulmonary capillary hemangiomatosis (PVOD/PCH; n=63). A gene panel was designed to focus on all exons and included  BMPR- 2 ,  EIF2AK4 ,  TBX4 ,  CAV1 ,  SMAD9 ,  KCNK3 ,  ACVRL1 ,  BMP9 ,  ENG , and  BMP10 . Using this gene pan...

DUBLIN--(BUSINESS WIRE)--Jan 28, 2019--The "Pulmonary Arterial Hypertension - Pipeline Insight, 2019" drug pipelines has been added to ResearchAndMarkets.com 's offering. Pulmonary Arterial Hypertension - Pipeline Insight, 2019 report offers comprehensive Insight of the pipeline (under development) therapeutics scenario and growth prospects across Pulmonary Arterial Hypertension development. The report provides detailed coverage of the pipeline landscape for this mechanism of action, equipped with data from multiple sources with complete pipeline analysis by developmental stage, associated indications, route of administration and molecule type. Pipeline therapeutics development coverage provides descriptive product profiles including (but not limited to) drug description, product development and R&D activities encompassing clinical and pre-clinical studies, designations, collaborations, licensing deals, grants, technologies and patent details. The report assess...

Source: Pexels. Making changes to your  diet  is a proven way to help control high blood pressure. These changes can also help you lose weight and lower your chance of heart disease and stroke. High blood pressure (hypertension) is the largest preventable and treatable risk factor for chronic disease in the world. More than 85 million people (1 in 3 adults) in the United States and more than 1 billion (40% of adults) in the world have hypertension. It is a major risk factor for stroke, heart attack, heart failure, and kidney failure. However, because it rarely produces symptoms, many people don’t know they have it, while many who have it do not control it adequately. Adapting the DASH Diet Hundreds of studies attest to the significant benefits of diet on blood pressure. The Dietary Approaches to Stop Hypertension (DASH) diet is the most tested and practical of the dietary approaches. It’s not really a diet, per se, but a way of eating specifically designed for ...

Hypertension (Photo Credits: Pixabay) New York, January 25:  Lower-than-normal levels of zinc -- a nutrient that helps the immune system fight off invading bacteria and viruses -- may contribute to hypertension, finds a new study on mice. The study, from the Wright State University in the US, demonstrated that the way in which the kidneys either excrete sodium into the urine or reabsorb it into the body -- specifically through a pathway called the sodium chloride cotransporter (NCC) -- also plays a role in controlling high blood pressure.  How Your Food Habits Are Causing High Blood Pressure. Zinc deficiency is common in people with illnesses such as Type-2 diabetes and chronic kidney disease. It also showed that less sodium in the urine typically corresponds with higher blood pressure. Zinc may help regulate proteins that in turn regulate the NCC, the study suggested.  Micronutrient Deficiencies That Indians Commonly Face. For the study, researchers compared ma...

Authors and Disclosures Author(s) Yasmine S. Ali, MD President, Nashville Preventive Cardiology, PLLC; Assistant Clinical Professor of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee Disclosure: Yasmine S. Ali, MD, has disclosed no relevant financial relationships. http://bit.ly/2WgKiD1

About the Author:   Dr. Daniel Yazdi is an Internal Medicine Resident at Brigham and Women’s Hospital/Harvard Medical School interested in the intersection of digital health and clinical medicine. He can be followed on Twitter @DanielYazdi. Watch- ing your blood pressure, pun intended, is about to have a new meaning. Early 2019 marks the release of the first FDA-approved smartwatch blood pressure cuff. Why is this big news? Hypertension affects about  75 million Americans , one out of three adults. It is the leading cause of cardiovascular disease (heart attacks and strokes), resulting in about 1,000 deaths per day. Only 50 percent of patients have their blood pressure adequately managed, demanding a better solution. The watch,  HeartGuide , will be released by Omron. It measures blood pressure by inflating the wrist band; a mechanism similar to that of a traditional cuff. Apple also submitted a  patent  in June 2018 for a similar device,...

Link found between zinc, blood pressure and kidney sodium transporter in mouse study Lower-than-normal zinc levels may contribute to high blood pressure (hypertension) by altering the way the kidneys handle sodium. The study is published ahead of print in the American Journal of Physiology--Renal Physiology . Zinc deficiency is common in people with chronic illnesses such as type 2 diabetes and chronic kidney disease. People with low zinc levels are also at a higher risk for hypertension. The way in which the kidneys either excrete sodium into the urine or reabsorb it into the body--specifically through a pathway called the sodium chloride cotransporter (NCC)--also plays a role in blood pressure control. Less sodium in the urine typically corresponds with higher blood pressure. Recent research has suggested that zinc may help regulate proteins that in turn regulate the NCC, but a direct link between zinc-deficiency-induced hypertension has not been examined. Related Stories Rese...

January 22, 2019 Share this content: Media coverage on the expanded definition of hypertension was largely positive but did not sufficiently cover information on potential harms. Media coverage on the expanded definition of hypertension was largely positive but did not sufficiently cover information on potential harms, conflicts of interest, or concerns raised among influential medical groups, according to a research letter published in  JAMA Internal Medicine . Investigators sought to examine how the media covered the benefits and harms of the expanded definition of hypertension from new guidelines put forth by the American College of Cardiology and the American Heart Association in 2017. Continue Reading Below The researchers performed a cross-sectional analysis of media coverage on the 2017 expanded definition of hypertension between November 2017 and July 2018 by searching ProQuest and PubMed databases for relevant English language articles; 100 stories, 15 press r...

[unable to retrieve full-text content] Novel Biomarker Identifies HF in Hypertension | Cardiology    Consultant360 Individuals with hypertension who have higher concentrations of fibroblast growth factor-23 (FGF23) are at a significantly higher risk for heart failure (HF), ... http://bit.ly/2CBzxlB