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Showing posts from September, 2024

New clinical trial design in precision medicine: discovery, development and direction

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medpace clinical trials :: Article Creator Assessing Medpace Hldgs: Insights From 9 Financial Analysts In the latest quarter, 9 analysts provided ratings for Medpace Hldgs MEDP, showcasing a mix of bullish and bearish perspectives. In the table below, you'll find a summary of their recent ratings, revealing the shifting sentiments over the past 30 days and comparing them to the previous months. Bullish Somewhat Bullish Indifferent Somewhat Bearish Bearish Total Ratings 2 3 4 0 0 Last 30D 0 0 1 0 0 1M Ago 0 1 1 0 0 2M Ago 0 0 1 0 0 3M Ago 2 2 1 0 0 Analysts provide deeper insights through their assessments of 12-month price targets, revealing an average target of $402.67, a high estimate of $469.00, and a low estimate of $336.00. A decline of 7.99% from the prior average price target is evident in the current average. Exploring Analyst Ratings: An In-Depth Overview A clear picture of Medpace Hldgs...

World Hypertension Day 2024: Theme, Significance And Why You Should Regularly Monitor BP

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preclinical trials :: Article Creator Neuroactive Drugs Show Promising Anti-glioblastoma Effects In Preclinical Trials Researchers find that the antidepressant vortioxetine may offer new hope for glioblastoma patients by crossing the blood-brain barrier and significantly reducing tumor size in preclinical models. Study: High-throughput identification of repurposable neuroactive drugs with potent anti-glioblastoma activity. Image Credit: Elif Bayraktar / Shutterstock.Com A recent Nature Medicine study evaluates the potential to repurpose currently approved drugs to treat cancer and neurological disorders for their therapeutic effects against glioblastoma.   Current treatment strategies for glioblastoma Glioblastoma is an incurable and fatal type of brain cancer, with about 50% of patients dying within twelve months of diagnosis. The life expectancy of glioblastoma patients can be extended through radiation, chemotherapy, or surgical inter...

Diabetic vascular diseases: molecular mechanisms and therapeutic strategies

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chronic fatigue after lyme disease :: Article Creator Prolonged Symptoms After Lyme Disease: What CDC Wants Doctors To Know A new toolkit can help physicians navigate the management of patients with prolonged symptoms after antibiotic treatment for Lyme disease, discussants said during a CDC webinar for clinicians last week. "Chronic Lyme disease is really so much more than a medical issue. It's a social phenomenon that's driven by a combination of patient desperation for answers, physician frustration, and also medical misinformation," said Grace Marx, MD, MPH, of the division of vector-borne diseases at the CDC. "So, as the physician, bringing a solid, science-based understanding of Lyme disease to these clinical encounters is very important." Erica Kaufman West, MD, director of infectious diseases for the American Medical Association (AMA), noted that Lyme disease is caused by an infection with Borrelia burgd...

Late-Breaking Science Abstracts and Featured Science Abstracts From the American Heart Association’s Scientific Sessions 2023 and Late-Breaking Abstracts in Resuscitation Science From the Resuscitation Science Symposium 2023

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neurological chronic diseases :: Article Creator 15 Neurological Autoimmune Diseases To Know About Neurological autoimmune diseases cause your immune system to attack your central or peripheral nervous systems. Multiple sclerosis is the most common and well-known, but several of these conditions exist. Autoimmune diseases cause your immune system to attack your body's healthy cells and tissues rather than infectious or harmful materials. When your immune system targets your nervous system, it affects the functions of your central nervous system (CNS) or peripheral nervous system (PNS). This can lead to neurological symptoms. If you develop sudden or gradual neurological symptoms, it's important to see a doctor. MS is a chronic and progressive autoimmune condition experts think may be due to a combination of genetic, immune, and environmental factors. numbness cognitive impairment vision problem...

Adverse effects of tyrosine kinase inhibitors in cancer therapy: pathophysiology, mechanisms and clinical management

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small vessel coronary disease :: Article Creator Stent Implantation Preferred Strategy For Previously Untreated Non-complex Coronary Artery Disease, States Study Novel drug-coated balloons (DCB) did not outshine standard treatment with second generation drug-eluting stents (DES) as they were expected to, in a surprise finding of the first randomised trial to compare clinical outcomes in previously untreated patients with non-complex disease undergoing percutaneous coronary intervention (PCI). The study was presented in a Hot Line Session at this year's ESC Congress 2024 in London, UK (30 Aug – 2 Sept). "Drug-coated balloon angioplasty failed to achieve non­inferiority compared to standard treatment with second-generation thin strut drug-eluting stents, mainly due to the need for more repeat procedures (revascularisation)," said senior author Dr Ling Tao from Xijing Hospital, Xi'an, China. Each year, millions of people a...

New clinical trial design in precision medicine: discovery, development and direction

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new treatments for pad 2020 :: Article Creator Peripheral Artery Disease: Leg Pain, Leg Cramps, Lingering Foot Wounds Among Symptoms Leg pain and leg cramps aren't always an orthopedic issue: Both can be signs of peripheral artery disease, or PAD, a serious blood-flow issue with implications for the heart. In this expert alert, Young Erben, M.D., a vascular surgeon at Mayo Clinic in Jacksonville, Florida, explains how the most common form, PAD that affects the legs and feet, is treated. Options include a surgical technique from the past that Mayo surgeons are reviving and refining to offer new hope to patients with advanced PAD. In peripheral artery disease, narrowed arteries reduce blood flow to the affected limbs. They do not get enough blood flow to keep up with the demand. It is important to manage PAD as early as possible, Dr. Erben says. In the worst cases, PAD can progress to open sores that do not heal, causing tissue death and lim...