Hypertension

pulmonary hypertension right heart failure :: Article Creator SMAD5 Is A Potential Novel Gene In Patients With Familial PAH Among patients with familial pulmonary arterial hypertension (PAH), SMAD5 appears to be a novel gene that warrants consideration for genetic testing, according to findings from a study conducted in Germany and published in Clinical Science (London). Individuals with the rare disorder PAH experience elevated pulmonary vascular resistance and right ventricular hypertrophy, which eventually lead to right heart failure. Of note, genetic mutations in 18 or fewer recognized PAH genes have been shown to be associated with abnormal proliferation and apoptosis of endothelial cells, pulmonary vascular smooth muscle cells, and fibroblasts. This, in turn, causes thickening of the pulmonary arterial walls. Approximately 85% of patients with familial PAH and 15% of those with idiopathic PAH present with a disease-associated mutation. The...

conduct clinical trials :: Article Creator The Main Challenges Of Conducting Clinical Trials: How To Overcome Them Clinical trials are essential for advancing medical knowledge and developing new therapies, yet they are complex endeavors fraught with challenges: From recruiting patients to navigating intricate regulations, the process requires careful planning, significant resources, and adaptability. To overcome these hurdles, a strategic approach and collaboration with a clinical research organization (CRO) can make all the difference. In this article, we'll explore the main challenges in conducting clinical trials and provide actionable strategies to address them, with a focus on improving recruitment, maintaining regulatory compliance, and managing data accuracy. Understanding the Key Challenges in Clinical Trials Clinical trials are multifaceted processes, and several factors can impede their progress; some of their main challeng...

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diet for cardiovascular disease :: Article Creator What To Know About The Mediterranean Diet, Ranked Best Diet For 8th Year In A Row The Mediterranean diet -- which emphasizes fruits, vegetables, lean proteins and whole grains -- has once again topped U.S. News and World Report's annual ranking of best diets. The publication on Friday named the diet the best overall diet for the eighth year in a row. The Mediterranean diet scored a 4.8 out of 5 based on an evaluation of several factors, including nutritional completeness, health risks and benefits, long-term sustainability and evidence-based effectiveness, according to U.S. News and World Report. The diet also scored the top spot in 11 additional categories in the publication's annual rankings, including easiest-to-follow, gut health, weight loss and mental health. The DASH (Dietary Approaches to Stop Hypertension), which focuses on whole foods and low sodium, was ranked second on th...

diet for heart blockage :: Article Creator Dear Abby: Why Should I Have To Follow My Wife's Heart-healthy Diet. I'm Fine! DEAR ABBY: My wife was recently diagnosed with a partial arterial blockage. It isn't blocked enough to warrant an angioplasty or a stent, so her doctors will manage it with medication and diet.Because my wife now has a special diet she must follow, she has told me I can no longer eat anything in front of her that she can't eat. I must eat only the food she eats. My health is good, and I have no dietary restrictions. Is this demand she is making of me fair? How do I deal with it? -- PUNISHED IN ILLINOIS DEAR PUNISHED: I suspect the diet you obliquely mentioned may be a "heart healthy" one. If that's the case, during the last 20 years (or so) the American Heart Association has published many cookbooks offering a variety of delicious recipes. (I know this to be true because I have di...

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cad triple vessel disease :: Article Creator Coronary Artery Disease Coronary artery disease occurs due to damage to the main blood vessels that supply oxygen and various nutrients through blood to the heart. These blood vessels are called coronary arteries. Deposition of cholesterol and formation of plaque (atherosclerosis) is the main reason that causes damage to these arteries. When the plaque builds up and hardens, it blocks the coronary arteries, which in turn reduces the flow of blood to the heart. Over the time, this plaque keeps building and when the blood flow is reduced drastically the main symptoms of coronary artery disease like chest pain (angina) and breathlessness are seen. Complete blockage of the artery leads to a heart attack. Because the process of deposition of cholesterol is gradual, progression of coronary artery disease goes unnoticed. Therefore, the best way to prevent coronary artery disease is to  follow a healthy...

complex chronic disease :: Article Creator Breakthroughs In Alzheimer's Research May Be Game-changers Research on Alzheimer's disease is approaching a much-needed tipping point. The media spotlight has been on newly available drugs like lecanemab and donanemab that target the protein plaques associated with the disease's progression. But a burgeoning consensus is emerging around a longstanding hypothesis that was once considered unorthodox and quixotic: Infections may trigger or exacerbate Alzheimer's disease and other neurological conditions. It's a straightforward hypothesis with profound implications for how we diagnose and treat a debilitating disease that impacts nearly 7 million Americans (and about 55 million people worldwide). Health-care and caregiving costs associated with Alzheimer's disease are believed to exceed $600 billion annually. A hallmark of Alzheimer's disease, the most common form of deme...

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