Fucoidan: A Potent Natural Adjuvant Representing a Possible Therapy in PAH - Pulmonology Advisor

January 17, 2019
Share this content:
Lung morphometry demonstrated that fucoidan significantly decreased the number of fully muscularized pulmonary arteries.
Lung morphometry demonstrated that fucoidan significantly decreased the number of fully muscularized pulmonary arteries.

Mice chronically exposed to hypoxia and given fucoidans exhibited improved vascular remodeling, right ventricular (RV) function, and an attenuated inflammatory response, according to study results published in the American Journal of Respiratory and Critical Care Medicine.

Mice induced with pulmonary hypertension (PH) by chronic hypoxia for 35 days were given either fucoidan (from Fucus vesiculosus), anti-P-selectin antibody (Rb40.34), or saline by intraperitoneal injection from days 21 through 35. Parameters associated with PH such as RV function, vascular morphometry, and inflammatory responses were compared between groups.

Continue Reading Below

Hypoxia exposure for 35 days resulted in significant RV hypertrophy confirming the occurrence of PH. Control mice also exhibited RV dilatation, increased RV systolic pressure, decreased stroke volume and cardiac output, and overall impaired RV function.

Fucoidan treatment led to a marked decrease in RV internal diameter as well as an increase in stroke volume, cardiac output, and tricuspid annular plane systolic excursion. Fucoidan treatment had no effect on RV systolic pressure. Overall, fucoidan significantly improves RV function in chronic hypoxia-induced PH. Furthermore, lung morphometry demonstrated that fucoidan significantly decreased the number of fully muscularized pulmonary arteries and significantly decreased the level of CD3-positive lymphocytes.

The researchers wrote, “Although fucoidan did not affect RV hypertrophy and RV [systolic pressure], our data clearly indicate that it significantly improved pulmonary remodeling and RV function and in parallel decreased [pulmonary vascular resistance index].”

Related Articles

Reference

Novoyatleva T, Kojonazarov B, Owczarek A, et al. Evidence for fucoidan-p-selectin axis as a therapeutic target on hypoxia-induced pulmonary hypertension [published December 17, 2018]. Am J Respir Crit Care Med. doi:10.1164/rccm.201806-1170OC



http://bit.ly/2T0AhI9
-

Comments

Post a Comment

Popular Posts

High blood pressure warning - the age you should definitely get checked for hypertension - Express

Image
High blood pressure is a common condition that puts extra stress on blood vessels and vital organs. Diagnosing the condition - which is also known as hypertension - early is crucial, as it raises the risk of some deadly complications, including heart disease and strokes. But making some small diet or lifestyle changes could help to lower your chances of developing high blood pressure . You should definitely get a blood pressure check as soon as you turn 60 years old, urged LloydsPharmacy. Hypertension is most common in people over 60 years old, said LloydsPharmacy. As soon as you’ve hit 60, it’s a good idea to speak to a doctor our pharmacist to check your blood pressure. Even if you only have slightly high blood pressure, diagnosing the condition early can help patients to kickstart their new lifestyle changes, it said. “It’s only natural that people might not think to seek help from a health professional until something starts to feel wrong, especially as we are all livin...
Read more

Real Stories From People Who Had a Surprising Gut Feeling That Turned Out to Be Correct - Obsev

Some people claim to have a sixth sense that lets them know when something is about to happen. Although most people aren't clairvoyant, there is some truth to having a gut feeling about future events. People have claimed to turn down job offers, decline evening plans and forgo vacations just because they had a feeling that things were about to take a turn for the worse. And when these feelings prove to be right, it's evident that maybe there is a reason that people have these instincts. The gut wrenching feeling that you have to act now just can't be ignored. Having a life-threatening experience is memorable enough, but narrowly avoiding one by seconds is just as unforgettable.   He's Still in Jail Unsplash My oldest daughter (30-something) stopped by my work one day and introduced her new boyfriend. He seemed a little off to me, but I decided it was just "guy dating my daughter" and let it go. La...
Read more

Atherosclerosis common in adults without heart disease, symptoms

Image
clinical trials day :: Article Creator Everyday Drug Discovery: How Tech Expands The Potential Of Clinical Trials And Recentres Participants Throughout my career in the development and implementation of technological solutions to support clinical research, I've been lucky enough to work closely with a wide range of so-called "stakeholders" in the clinical trial lifecycle, from regulators, drug development research teams, site staff, and patients.  While all groups have demonstrated an inspiring level of dedication and passion, I have always been moved by patients' willingness to sacrifice their time and adapt their care plans to take part in clinical trials, fully understanding they might not directly benefit from the treatment being tested, though so often desperately hoping they do. Patients recognise the importance of clinical research to the long term success in treating diseases of all kinds, and in turn the industry has t...
Read more