Hypertension

rct clinical trial :: Article Creator 'Breakthrough' CRISPR Treatment Slashes Cholesterol In First Human Clinical Trial CRISPR-based therapies just hit another milestone. In a small clinical trial with 10 people genetically prone to dangerously high levels of cholesterol, a single infusion of the precision gene editor slashed the artery-clogging fat by up to 55 percent. If all goes well, the one-shot treatment could last a lifetime. The trial, led by Verve Therapeutics, is the first to explore CRISPR for a chronic disease that's usually managed with decades of daily pills. It also marks the first use of a newer class of gene editors directly in humans. Called base editing, the technology is more precise—and potentially safer—than the original set of CRISPR tools. The new treatment, VERVE-101, uses a base editor to disable a gene encoding a liver protein that regulates cholesterol. To be clear, these results are just a sneak peek in...

trial treatment :: Article Creator Trial Results Support 'new Gold Standard' For Head And Neck Cancer Radiotherapy Phase III trial results on a precision radiotherapy technique support a "new gold standard" for treating head and neck cancer patients. The research suggests the new approach can reduce the risk of swallowing problems after radiotherapy, without impacting the success of treatment. The Dysphagia-Aspiration Related Structures (DARS) trial compared dysphagia-optimized intensity-modulated radiotherapy (DO-IMRT) with standard IMRT. Reducing radiation to muscles involved in swallowing DO-IMRT optimizes IMRT to reduce the risk of swallowing difficulties, known as dysphagia. This common side effect of radiotherapy for head and neck cancer can, in some cases, leave patients needing a permanent feeding tube. DO-IMRT lowers the risk of dysphagia by reducing radiation to the pharyngeal muscles, which support swallowing. ...

natalee trial breast cancer :: Article Creator Novartis Kisqali NATALEE Analysis Reinforces Consistent Reduction In Risk Of Recurrence Across Key Subgroups Of Patients With Early Breast Cancer Novartis will present late-breaking results from a prespecified exploratory subgroup analysis of invasive disease-free survival (iDFS) from the pivotal phase III NATALEE trial at the European Society for Medical Oncology (ESMO) Congress 2023. After 27.7 months of follow-up, the iDFS benefit with Kisqali (ribociclib) plus endocrine therapy (ET) was consistent across key prespecified subgroups, compared to ET alone, in patients with stage II and III hormone receptor-positive/human epidermal growth factor receptor 2-negative (HR+/HER2-) early breast cancer (EBC) (see table below)1. Results were also consistent with those in the overall trial population, reinforcing that the benefit was not driven by a specific patient subgroup. "Subgroup analyses provide a m...

hypertensive disease :: Article Creator How High Cholesterol And Hypertension Increase Heart Disease Risks In Younger Adults In a new study, researchers say younger people may be more vulnerable to developing cardiovascular problems than previously believed. They say young adults need to pay more attention to cardiovascular risk indicators such as cholesterol and high blood pressure at an early age. Experts say early lifestyle modifications can reduce the risk of heart problems later in life. Cardiovascular issues aren't just a concern for the young at heart. A new study says younger adults may be at a greater risk for developing artery-narrowing atherosclerosis and may be especially vulnerable to the effects of elevated blood cholesterol and hypertension, two typical modifiable cardiovascular risk factors. Undertaken at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) in Spain, the research concludes that people need...

multiple chronic diseases :: Article Creator How To Cope With Multiple Chronic Illnesses Source: Photo by Ivan Aleksic on Unsplash "How do you do it? You live with migraine, POTS (Postural Orthostatic Tachycardia Syndrome), IBS (Irritable Bowel Syndrome), and two herniated discs in your lower back? "What?! You also lived with severe endometriosis before a total hysterectomy and a follow-up surgery so the doctors could remove the live tissue left behind?" "Well, how do you do it, living with fibromyalgia, chronic fatigue syndrome, and Crohn's disease?" These are the plights of me and one of my close friends. I'm sure if you are reading this post, you have your own scenario or a loved one who does. Any of us who lives with multiple chronic illnesses faces the realities of the very definition of chronic: Chronic diseases are defined broadly as conditions that last one year or more and require ongoing...