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The Best Supplements For Relieving Stress And Boosting Your Mood, According To Experts

M. Aurum Aogashima: The main ingredient in Immy, this beneficial bacteria is derived from soil and has helped humans for eons by reducing chronic inflammation. As society has shifted to more urban living (when was the last time you played in the dirt?), we encounter the bacteria and its benefits far less frequently. "Years of research indicates that it can positively impact the immune system, diminish chronic inflammation via the gut-brain axis, lower pro-inflammatory markers, and increase stress resilience," says Syn.

Fiber: Considering the importance of your gut-brain axis in regulating stress, you want to make sure you're giving your gut the support it needs. "Fiber stands out as one of the most extensively studied agents for maintaining a healthy gut microbiome, with substantial evidence supporting its effectiveness and a very low risk profile," says Dr. Schehr. Fiber is food for your gut microbiome, helping them produce short-chain fatty acids that can reduce inflammation, in turn reducing stress. When paired with adequate protein, fiber intake can also help regulate your blood sugar. "Drastic fluctuations in blood sugar promote the release of stress hormones including cortisol and adrenaline, which can exacerbate feelings of irritability, fatigue, and anxiety," adds Dr. Schehr.

Magnesium: This is a key element that our bodies need hundreds of different cellular processes. "It's most commonly absorbed dietarily from vegetables, but overfarming has led to many of our vegetables—organic and everything in between—to not have the same level of nutrients for healthy body support," explains Baczewski. He notes that deficiencies aren't always reflected in bloodwork, but you can keep an eye out for low magnesium symptoms like anxiety, muscle spasms, restless legs, inability to stay asleep, or headaches. "The best-absorbed magnesium supplements are magnesium chelate and magnesium glycinate," he says. Dr. Schehr adds that magnesium supports your body's production of melatonin: "Improved sleep quality is crucial for managing stress effectively," she says.

Ashwagandha: Ashwagandha is a shrub that grows throughout South Asia, the Middle East, and parts of Africa. It's an adaptogen, meaning it helps the body manage stress and restore balance, explains Syn. There are clinical trials documenting ashwagandha's efficacy in improving stress, anxiety, and sleep.

L-theanine: This amino acid is naturally found in green tea and some mushrooms. "It stimulates the production of alpha brain waves, which are associated with a relaxed but alert state," says Dr. Schehr, which means it can help reduce feelings of stress and anxiety without dulling your mental clarity or focus. "It may also reduce the activation of the sympathetic nervous system, which is responsible for the 'fight-or-flight' response," she adds. "By promoting parasympathetic activity—the 'rest-and-digest' system—it helps the body manage stress more effectively."

Rhodiola: This is another adaptogenic plant, more specifically a type of succulent, which grows in cold, high-altitude areas. Studies show that it can help relieve stress, fatigue, and burnout as well as support cardiovascular and reproductive health with its antioxidant function.

Vitamin D: As mentioned, vitamin D is a common deficiency in the United States, with studies showing that it's especially deficient in Black and Hispanic individuals. You're also more likely to experience a vitamin D deficiency if you live somewhere with a cold winter, as our body synthesizes the nutrient with the help of sun exposure. Vitamin D is responsible for a lot of bodily functions, but most notably bone health and cognitive health. "If you live in an area like New England, regular supplementation is absolutely necessary," says Baczewski. "Typical recommendation for oral supplementation is 2,000 to 5,000 units per day, but I encourage closer to 5,000 units if the client is in colder climates."

How to Choose the Best Supplements for Stress

It's important to remember that unlike pharmaceutical products, supplements aren't regulated by the FDA. "The quality of supplements matters, and as a consumer, it can be difficult to accurately assess their quality," warns Dr. Schehr. She recommends looking for specific certifications that can indicate higher manufacturing standards and provide reassurance about the product's safety and efficacy. This includes United States Pharmacopeia (USP) Verified, ISO certification, Non-GMO Project Verified, and allergen-free certifications. You should also speak to your provider before trying any new supplements, especially if you are on certain drugs, including those that treat depression, anxiety, or heart conditions. "Your healthcare provider can help assess any potential interactions or contraindications based on your personal health history," says Syn.

Once you've found reputable brands, seek out a supplement designed to address your main concern. Dr. Schehr recommends introducing one supplement at a time to clearly assess its effectiveness. "If you're dealing with chronic or complex stress symptoms, consulting an expert is essential to determine the best approach," she adds. And ultimately, know that you can't expect a supplement to be a complete cure. While it's often easier said than done, you'll have to do some work on your own to help alleviate stressors in your daily life. "For any stress support supplement to be truly effective, it must be paired with proactive stress management," explains Dr. Schehr. "This includes eating a nutritious diet, avoiding stimulants, establishing a solid sleep routine, and incorporating calming practices such as meditation or breathwork."

Meet the Experts

Mia Syn is a registered dietician, author, and on-air expert in New York, NY.

Dr. Jaime Schehr is a naturopathic, registered dietitian, and the Assistant Director of Academic Integrative Family Medicine at the Institute for Family Health of Mount Sinai in New York, NY.

Joe Baczewski is a registered nurse and the co-founder of LIVation, a wellness clinic in Madison, CT.

Top 6 Best Calming Supplements For Anxiety In 2025

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Numerous people who are combating stress and anxiety usually choose tranquility-enhancing supplements as a means of promoting relaxation. These supplements come in various forms such as capsules, tablets, powders, and liquids. The optimal calming supplement is determined by individual requirements and preferences. Some of these supplements contain natural constituents like herbs, vitamins, and minerals, and others could possibly contain manufactured compounds.

When choosing the best calming supplement, it is essential to consider the ingredients, dosage, and potential side effects. Some supplements may interact with medications or cause adverse reactions, so it's crucial to consult with a healthcare professional before taking any new supplements.

In this article, we spent countless hours researching and testing ten calming supplements to identify the ones that are effective, safe, and reliable. We evaluated the ingredients, dosage, and customer reviews to determine the best calming supplement for different needs and preferences.

Best Calming Supplements

We understand that stress and anxiety can take a toll on our mental and physical health. To help you find some relief, we've rounded up the best calming supplements on Amazon. These supplements are formulated with natural ingredients that are known for their calming properties. Whether you're looking for something to help you relax after a long day or to ease your anxiety during stressful situations, we've got you covered. Check out our top picks below.

1. Purina Pro Plan Veterinary Supplements Calming Care Canine Formula Dog Supplements

If you're looking for a safe and effective calming supplement for your dog, Purina Pro Plan Veterinary Supplements Calming Care Canine Formula Dog Supplements could be a great option.

Pros

This calming supplement is recommended by veterinarians, making it a trustworthy choice for pet owners.

It helps dogs maintain calm behavior, especially in stressful situations brought on by separation anxiety, changes in routine, and loud noises.

The formula is designed to support a reduced cortisol response and positive cardiac activity during stressful events.

Cons

The product may not work for all dogs, as every pet is unique and may require different solutions to manage anxiety.

It may take some time for the calming supplement to take effect, so pet owners should be patient and consistent in administering it.

The product contains only one strain of beneficial bacteria, which may not be enough to address all types of anxiety-related behaviors in dogs.

We recently tried Purina Pro Plan Veterinary Supplements Calming Care Canine Formula Dog Supplements on our dog, who tends to get anxious during thunderstorms and other loud events. We were pleased to see that the supplement helped calm her down and reduce her anxious behaviors, such as excessive vocalization and pacing. We also appreciated how easy it was to administer the product by simply adding it to her regular food.

One thing to keep in mind is that every dog is different, and what works for one pet may not work for another. It's important to be patient and consistent when trying out calming supplements, and to consult with a veterinarian if you have any concerns about your pet's anxiety.

Overall, we would recommend Purina Pro Plan Veterinary Supplements Calming Care Canine Formula Dog Supplements to pet owners looking for a safe and effective way to manage their dog's anxiety.

2. Dr Amen BrainMD GABA Calming Support

If you're looking to reduce anxiety and promote relaxation, Dr Amen BrainMD GABA Calming Support might be worth trying.

Pros

Natural ingredients promote calmness and relaxation

Contains lemon balm, which is known to help people relax

Suitable for all ages

Cons

Might not work for everyone

A bit pricey compared to other calming supplements

Some people might experience side effects like headaches or dizziness

We tried Dr Amen BrainMD GABA Calming Support and found that it helped reduce anxiety and promote relaxation. The natural ingredients, including GABA, lemon balm, and magnesium, helped us feel more calm and centered. We also appreciated that the supplement is suitable for all ages and contains no artificial ingredients.

However, we did notice that the supplement might not work for everyone. Some people might experience side effects like headaches or dizziness, and the supplement is a bit pricey compared to other calming supplements on the market.

Overall, if you're looking for a natural way to reduce anxiety and promote relaxation, Dr Amen BrainMD GABA Calming Support might be worth trying. Just be aware that it might not work for everyone and could cause side effects in some people.

3. EverRoot Calming Dog Supplement

If you're looking for a natural way to calm your dog, then you should consider the EverRoot Calming Dog Supplement.

Pros

Made with organic ingredients

Non-GMO project verified

No artificial colors, flavors or preservatives

Cons

Strong turmeric smell

May not work for all dogs

Some dogs may not like the taste

This supplement contains chamomile and L-theanine from green-tea extract to help support dog anxiety relief while fostering holistic health. It is formulated by Dr. Brian, a PhD of Animal Nutrition at Purina, to help dogs deal with environmentally induced stressors.

We tried this supplement on our dog who tends to get anxious during thunderstorms and fireworks. We noticed that it helped calm her down and made her less agitated. We also appreciate that it is made with organic ingredients and is non-GMO project verified.

However, we did notice that the supplement has a strong turmeric smell which may not be appealing to all dogs. Additionally, it may not work for all dogs and some may not like the taste.

Overall, we would recommend the EverRoot Calming Dog Supplement to anyone looking for a natural way to calm their dog.

4. NutraChamps CalmSense Stress Relief Supplement

If you're looking for a natural way to relieve stress and anxiety, NutraChamps CalmSense Stress Relief Supplement might be the perfect solution for you.

Pros

CalmSense's natural ingredients work together to help restore positive energy and relieve stressed nerves.

The soothing ingredients in CalmSense have been clinically shown to relax and calm the body while also boosting clarity, focus, and flow.

CalmSense's herbal blend is gentle and safe, with no side effects.

Cons

Some users may not experience the desired effects with CalmSense.

The recommended dosage may not be suitable for everyone.

CalmSense may not work for severe anxiety or panic disorders.

We've been using CalmSense for a few weeks now, and we've noticed a significant improvement in our mood and stress levels. The herbal blend is gentle and safe, and we haven't experienced any side effects. We take one capsule in the morning and another in the mid-afternoon, and we feel relaxed and focused throughout the day.

CalmSense is also great for unwinding after a long day at work or helping eliminate daily stresses. It puts us into the ideal state of mind for getting things done without feeling sluggish or zonked.

Overall, we highly recommend NutraChamps CalmSense Stress Relief Supplement to anyone looking for a natural way to relieve stress and anxiety.

5. NaturVet Quiet Moments Calming Aid Dog Supplement

We highly recommend the NaturVet Quiet Moments Calming Aid Dog Supplement for pet owners who want to help their dogs relax and stay calm during stressful situations.

Pros

The supplement is made with high-quality ingredients that promote normal nervous system function in dogs.

It contains melatonin, ginger, L-Tryptophan and thiamin, which are all known to reduce tension and stress in dogs.

The soft chews are tasty and packaged in a re-sealable jar for continued freshness.

Cons

Some dogs may not like the taste of the soft chews.

The supplement may not work for all dogs.

The price may be a bit high for some pet owners.

We have used this supplement with our own dogs during thunderstorms and car rides, and we have seen a noticeable difference in their behavior. The soft chews are easy to give to our dogs, and they seem to enjoy the taste. We also appreciate that the supplement is made with high-quality ingredients and is manufactured in the USA.

If you are looking for a way to help your dog stay calm during stressful situations, we highly recommend the NaturVet Quiet Moments Calming Aid Dog Supplement. Give it a try and see if it works for your furry friend!

6. Purina Calming Care Canine 45ct, 3pk

We highly recommend Purina Calming Care Canine 45ct, 3pk for dogs who need help in maintaining calm behavior.

Pros

The proprietary use of probiotic strain BL999 helps dogs maintain calm behavior and positive cardiac activity during stressful events.

It helps support dogs with anxious behaviors such as excessive vocalization, jumping, pacing, and spinning.

It helps dogs cope with external stressors like separation, unfamiliar visitors, novel sounds, or changes in routine and location.

Cons

Results may vary depending on the dog's age, breed, and severity of anxiety.

It may take some time before seeing significant changes in the dog's behavior.

The tablet form may not be ideal for dogs who are difficult to give medication to.

We have tried Purina Calming Care Canine 45ct, 3pk on our dog who is prone to anxiety during thunderstorms and fireworks. We have noticed a significant improvement in his behavior during these events. He no longer hides under the bed or whines uncontrollably. The tablet form is easy to give and does not cause any adverse side effects.

In addition, we appreciate that the product uses a probiotic strain that is backed by scientific research. It gives us peace of mind knowing that we are giving our dog a safe and effective supplement.

Overall, we believe that Purina Calming Care Canine 45ct, 3pk is a worthwhile investment for dog owners who want to help their furry friends manage their anxiety.

Buying Guide

When it comes to choosing the best calming supplement, there are a few key features to look for to ensure that you are getting a high-quality product that will be effective for your needs.

First, consider the ingredients. Look for supplements that contain natural ingredients such as herbs, vitamins, and minerals that have been shown to have calming effects. Avoid products that contain artificial ingredients or fillers that may be harmful or ineffective.

Next, consider the dosage and recommended use. Make sure that the supplement provides clear instructions on how much to take and how often. It's important to follow these instructions carefully to ensure that you are getting the full benefits of the supplement.

Another important factor to consider is the reputation of the manufacturer. Look for companies that have a good reputation for producing high-quality, effective supplements. You may want to do some research online to read reviews and see what other customers have to say about the product.

Finally, consider any additional features or benefits that the supplement may offer. For example, some supplements may also contain ingredients that support overall health and wellbeing, such as antioxidants or probiotics. Others may come in different forms, such as capsules, powders, or liquids, to suit your preferences.

Overall, choosing the best calming supplement requires careful consideration of the ingredients, dosage, manufacturer reputation, and any additional features that may be important to you. By taking the time to research and compare different products, you can find a supplement that will help you feel calm, relaxed, and centered.

Frequently Asked Questions What are some natural supplements for anxiety and stress?

There are several natural supplements that may help reduce anxiety and stress, including ashwagandha, valerian root, passionflower, and chamomile. These supplements have been traditionally used to ease anxiety and promote relaxation.

What is the number one vitamin for anxiety?

Vitamin B complex is often considered the number one vitamin for anxiety. It contains several B vitamins that are essential for brain function and may help reduce anxiety symptoms. Some studies have also shown that vitamin D may help alleviate anxiety symptoms.

What are some natural supplements for anxiety and depression?

Some natural supplements that may help reduce symptoms of anxiety and depression include St. John's Wort, omega-3 fatty acids, and SAM-e. These supplements have been shown to have a positive effect on mood and may help alleviate symptoms of anxiety and depression.

What are some anxiety supplements for adults?

Some supplements that may help reduce anxiety in adults include magnesium, L-theanine, and kava. These supplements have been shown to promote relaxation and reduce anxiety symptoms.

What are some natural supplements for panic attacks?

Some natural supplements that may help reduce symptoms of panic attacks include passionflower, valerian root, and kava. These supplements have been traditionally used to promote relaxation and may help alleviate symptoms of panic attacks.

What is the best pill to naturally calm nerves?

There is no one-size-fits-all answer to this question as different supplements may work differently for different people. However, some supplements that may help calm nerves include ashwagandha, magnesium, and L-theanine. It's important to consult with a healthcare professional before taking any supplements to ensure they are safe and effective for you.

Boost Your Stress Relief With These Game-changing Vitamins

Managing stress is crucial to overall health and well-being. Stress can lead to numerous health issues, including heart disease, digestive problems, and mental health disorders. Therefore, incorporating vitamins and minerals into your daily routine may be an effective strategy for enhancing your body's ability to cope with stress. This article provides insight into some of the best vitamins and supplements for stress relief, along with their benefits and how they support mental health.

Key vitamins and their benefits

Several vitamins and supplements are known for their stress-relieving properties. These nutrients play a significant role in maintaining balance in the body's stress response system, supporting mood regulation, and providing the energy needed to manage daily pressures. Here's an overview of some of the most effective vitamins for stress relief:

Rhodiola roseaRhodiola rosea is an adaptogen known for its ability to enhance the body's stress resistance. By stimulating the body's natural stress response system, Rhodiola rosea can help reduce fatigue, improve concentration, and increase energy levels. This herb has been shown to support mental clarity and overall well-being, especially in high-stress situations. Studies suggest that it can reduce symptoms of anxiety and improve mood, making it a valuable tool for stress management.

Magnesium glycinateMagnesium is a vital mineral that helps regulate the body's stress response and plays a key role in calming the nervous system. Magnesium glycinate, a more absorbable form of magnesium, is known for its gentle effect on the digestive system. This form of magnesium has antioxidant and anti-inflammatory properties, which may help reduce pain, ease muscle tension, and support better anxiety management. Magnesium also promotes healthy sleep, which is essential for effective stress management.

AshwagandhaAshwagandha is another adaptogen that helps balance cortisol, the primary stress hormone in the body. High levels of cortisol can lead to chronic stress and anxiety, so managing cortisol levels is crucial. Ashwagandha not only helps lower cortisol but is also known for boosting energy and enhancing resilience to stress. Additionally, it has mood-stabilizing effects and can help improve focus and concentration during periods of high stress.

L-TheanineL-Theanine, found in green tea, is a natural compound known for its calming effects on the brain. It promotes relaxation without causing drowsiness and may also help improve cognitive function and memory. Research suggests that L-theanine increases alpha brain wave activity, which promotes a relaxed yet alert state, making it an effective stress-reducing supplement for those who need to remain focused under pressure.

Vitamin DVitamin D plays a critical role in mood regulation and mental health. It is essential for brain health, and low levels of vitamin D have been associated with an increased risk of anxiety, depression, and other mood disorders. Ensuring adequate vitamin D intake can help balance mood, reduce feelings of stress, and improve overall mental well-being. Sunlight exposure is the most natural source of vitamin D, but supplements are often necessary, particularly in regions with limited sunlight or during the winter months.

B vitaminsThe B vitamin family, which includes B1 (thiamine), B2 (riboflavin), B3 (niacin), B6, B9 (folate), and B12, plays a vital role in energy production and cognitive function. These vitamins help support the nervous system and are essential for proper brain function. Deficiencies in B vitamins can lead to fatigue, mood swings, and difficulty concentrating. Supplementing with B vitamins may help alleviate some of the physical and mental effects of stress, improving focus and reducing feelings of overwhelm.

GinsengGinseng is a powerful herb that has been used for centuries to support vitality and improve the body's ability to cope with stress. Ginseng is known to enhance energy levels, promote mental clarity, and reduce fatigue. It may also boost immune function, which can be compromised during periods of chronic stress. Ginseng's ability to support overall resilience makes it an excellent supplement for individuals facing high-stress situations.

Choosing the right vitamin for stress

When selecting a stress management supplement, it's important to look for products that are third-party tested and backed by scientific research. Not all supplements are created equal, and some may contain unnecessary fillers or additives that could reduce their effectiveness. Consulting with a health care provider is always recommended before adding any new supplement to your regimen, especially if you have any underlying health conditions or are taking other medications.

In addition, it's important to prioritize supplements that suit your individual needs. For example, if you experience stress-related insomnia, magnesium glycinate or L-theanine may be beneficial. If you struggle with mental clarity, Rhodiola rosea or ginseng may be better suited for your needs. A health care provider can help determine which supplements will work best based on your specific symptoms.

Comprehensive stress management

While vitamins and supplements can aid in stress management, they should not be the sole solution. A holistic approach to managing stress includes a well-rounded routine that incorporates various lifestyle habits. Regular physical activity, a balanced diet, adequate sleep, and relaxation techniques, such as yoga or mindfulness meditation, all play a crucial role in mitigating stress.

Sleep is especially important in stress management. Chronic sleep deprivation can exacerbate stress and anxiety, leading to a cycle of poor health. Ensuring 7-9 hours of quality sleep each night can help reduce stress levels and improve cognitive function. Additionally, maintaining a diet that includes stress-relieving foods, such as leafy greens, nuts, and seeds, can support overall health.

The importance of a balanced approach

When it comes to managing stress, vitamins can serve as valuable tools to enhance your body's ability to cope. However, they are most effective when combined with a healthy lifestyle and a balanced approach to mental health. While supplements can help fill nutritional gaps and support the body during times of stress, long-term stress relief requires consistency and a commitment to overall well-being.

Consulting with a health care provider and incorporating stress-relieving vitamins into a comprehensive health routine can help you manage stress effectively. By taking a proactive approach to stress management, you can enhance both your physical and mental resilience, ultimately improving your overall quality of life.

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