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Exercise Volume Versus Intensity and the Progression of Coronary Atherosclerosis in Middle-Aged and Older Athletes: Findings From the MARC-2 Study | Circulation

top chronic illnesses :: Article Creator

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Group meditation curbs stress, whether you do it or not: study - New York Post

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What you don't know about high blood pressure can kill you - The Daily Herald

What you don't know about high blood pressure can kill you The Daily Herald

6 Facts About Preeclampsia You Must Know - International Business Times

6 Facts About Preeclampsia You Must Know International Business Times Preeclampsia can be a serious complication during pregnancy and here are some essential facts about the condition.

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Group meditation curbs stress, whether you do it or not: study - New York Post

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When blood pressure refuses to budge: exploring the complexity of resistant hypertension

curcumin clinical trials :: Article Creator Curcumin Compound Reactivates Epstein–Barr Virus, Offering Safer Cancer Therapy A new study reveals how C210, a curcumin derivative, selectively reactivates Epstein–Barr virus to kill cancer cells without infectious risks, paving the way for safer, targeted cancer therapies. Study: Curcumin derivative C210 induces Epstein–Barr virus lytic cycle and inhibits virion production by disrupting Hsp90 function. Image Credit: Stephanie Frey / Shutterstock A study published in the journal Scientific Reports identifies a novel curcumin derivative that can effectively induce the Epstein–Barr virus (EBV) lytic cycle by disrupting heat shock protein 90 (HSP90). Background Epstein–Barr virus (EBV) is a tumorigenic virus associated with a range of cancer types, including epithelial cancers and lymphomas. The virus persists in cancer cells in a latent state, and viral reactivation from the latent state to the l...

2023 AHA/ACC/ACCP/ASPC/NLA/PCNA Guideline for the Management of Patients With Chronic Coronary Disease: A Report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines | Circulation

arteriosclerosis is a major cause of cad :: Article Creator

Obesity and cardiovascular disease: An executive document on pathophysiological and clinical links promoted by the Italian Society of Cardiovascular Prevention (SIPREC)

conduct clinical trials :: Article Creator The Main Challenges Of Conducting Clinical Trials: How To Overcome Them Clinical trials are essential for advancing medical knowledge and developing new therapies, yet they are complex endeavors fraught with challenges: From recruiting patients to navigating intricate regulations, the process requires careful planning, significant resources, and adaptability. To overcome these hurdles, a strategic approach and collaboration with a clinical research organization (CRO) can make all the difference. In this article, we'll explore the main challenges in conducting clinical trials and provide actionable strategies to address them, with a focus on improving recruitment, maintaining regulatory compliance, and managing data accuracy. Understanding the Key Challenges in Clinical Trials Clinical trials are multifaceted processes, and several factors can impede their progress; some of their main challeng...

Primary Aldosteronism and Ischemic Heart Disease

coronary flow :: Article Creator Young Men Who Take Steroids Have Impaired Coronary Flow, Even After Quitting Young men who use anabolic-androgenic steroids, or those who've used them in the past, are more likely to have reduced myocardial flow reserve than those who've never taken the drugs, according to Danish data. The findings, researchers say, suggest that "supraphysiologic doses of testosterone and synthetic steroids could have adverse impacts in coronary microcirculation." Led by Yeliz Bulut, MD (Copenhagen University Hospital-Rigshospitalet, Denmark), the study was published Monday in JAMA Network Open. Senior investigator Caroline Kistorp, MD, PhD (Copenhagen University Hospital-Rigshospitalet), told TCTMD that her interest in the topic was borne out of her own clinical experience as an endocrinologist seeing men present with steroid side effects, as well as growing awareness of the adverse effects these performance-en...

Association Between Consumption of Fermented Food and Food-Derived Prebiotics With Cognitive Performance, Depressive, and Anxiety Symptoms in Psychiatrically Healthy Medical Students Under Psychological Stress: A Prospective Cohort Study

pfizer volunteers :: Article Creator Coronavirus Vaccine Volunteers Describe 'severe Hangover' Side Effects From Jab Volunteers on the Pfizer coronavirus vaccine trial say they suffered side effects. [Courtesy] Volunteers on the Pfizer coronavirus vaccine trial say they suffered side effects comparable to a flu jab, with one comparing them to "a severe hangover". Among them was Carrie, a 45-year-old from the US state of Missouri, who said she suffered a headache, fever and aches over her body. She said the side effects after her first shot were like those of a flu jab, and more severe after the second. Glenn Deshields, a lobbyist from Austin, Texas, compared the side effects to "a severe hangover". Mr Deshields, 44, said he subsequently scheduled an antibody test through his doctor and it came back positive, so he was confident he had not received the placebo. He said his own immune reaction to the shot made him ...

2023 AHA/ACC/ACCP/ASPC/NLA/PCNA Guideline for the Management of Patients With Chronic Coronary Disease: A Report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines | Circulation

congenital heart disease symptoms :: Article Creator Heart Disease: Types, Causes, And Symptoms Heart disease isn't just one thing. It's a number of conditions that can affect how your heart works. Heart disease can also be called cardiovascular disease, though that term covers blood vessels problems as well. Heart disease is a major killer in the U.S., causing about 1 in 5 deaths, or about 700,000 a year. Each type of heart disease has its own symptoms and treatment. If you have some kinds, lifestyle changes and medicine can make a huge difference in your health. For others, you may need surgery to make your ticker work well again. Here are some of the common types of heart disease and how to prevent, recognize, and treat them. Heart disease can affect different parts of your heart and circulatory system, including arteries that carry blood to and from the heart and valves that open and close to keep blood moving in the right...

Understanding the relationships between physiological and psychosocial stress, cortisol and cognition

regeneron trials :: Article Creator Regeneron Says Study Data Support Big Bet On New Blood Thinners Dive Brief: Regeneron Pharmaceuticals intends to advance two blood-thinning drugs into Phase 3 testing next year after mid-stage study results showed they matched or surpassed marketed medicines at preventing blood clots following knee replacement surgery. Regeneron's drugs block a clotting protein, Factor XI, that's been targeted by multiple pharmaceutical companies, some of which have candidates in large, late-stage trials. The data announced Thursday are "proof-of-concept" results that Regeneron said give it confidence to follow suit. Factor XI blockers have produced mixed results so far in testing, however. Even if approved, they could face commercial challenges, as the effective blood thinner Eliquis is taken orally, rather than via infusion, and generic versions could arrive in 2026. Dive Insight: Regeneron needs it...

Association of pulse pressure and aortic root diameter in elderly Chinese patients with chronic heart failure

coronary artery imaging :: Article Creator Terumo Health Outcomes And Medis Strike Cardiovascular Care Partnership US-based Terumo Health Outcomes (THO) has entered a partnership with Netherlands-based Medis Medical Imaging (MMI) to enhance cardiovascular care in the US. The companies plan to combine MMI's non-invasive quantitative flow ratio (QFR) technology, a software for angiography-derived coronary physiology assessment, with Terumo's ePRISM clinical decision platform and pilot them together at select clinical sites in the US. Under the partnership, real-time data from electronic health records (EHRs), and data from Medis' PIONEER IV trial (NCT04923191) – a 2,540-patient study designed to evaluate the superiority of the company's next-generation QFR technology – will be integrated into THO's ePRISM platform. The companies anticipate that the combined technologies will enhance clinical decision support capabilities, s...

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